TY  - BOOK
AU  - Bhattarai,Abhinav.
TI  - Serum calcium phosphate product as a predictor of mortality in hospitalized patients
PY  - 2023///
KW  - Serum
KW  - Calcium phosphate
KW  - Predictor of mortality
KW  - Hospitalized patients
N1  - Thesis Report
N2  - ABSTRACT:

Background and aim: Recent studies have shown that elevated calcium phosphate arithmetic product (CaP) can lead to 
extraosseous calcifications and increase the risk of death. The aim of this study was to compare 
the admission CaP between survivors and non survivors and investigate if that could predict the 
survival outcomes in critically ill non-CKD patients. 

Methods: Altogether 126 study participants were enrolled which comprised of 3 cohorts: 52 critically ill non
CKD patients, 49 CKD patients and 25 healthy subjects. Blood samples were collected within 24 
hours of admission and calcium, phosphate, and CaP were estimated. Statistical analysis was 
performed on SPSS version 25. 

Results: The admission levels of phosphate, and CaP were significantly higher in non-survivors (p= 0.002 
and 0.011). Regression analysis revealed that phosphate (r2=0.170, p= 0.002) and CaP (r2=0.122, 
p= 0.011) could significantly predict mortality. ROC analysis showed satisfactory performance of 
admission phosphate and CaP (AUC= 0.719 and 0.621) in classifying patients at risk of mortality. 
Kaplan-Meier survival analysis showed the lowest survival rates in admission CaP < 22 mg2/dL2 
and > 43 mg2/dL2. 

Conclusion: Abnormal CaP is associated with increased incidence of mortality in critically ill patients and 
measuring CaP at admission can be a useful tool to predict the survival outcomes.
ER  -