000			02046nam a22002297a 4500
005			20230728123542.0
008			230728b |||||||| |||| 00| 0 eng d
040			_eNLM
060			_aTHS-00723
100			_aBhattarai,Abhinav.
245			_aSerum calcium phosphate product as a predictor of mortality in hospitalized patients.
260			_cc2023.
300			_a74p.
500			_aThesis Report.
520			_aABSTRACT: Background and aim: Recent studies have shown that elevated calcium phosphate arithmetic product (CaP) can lead to extraosseous calcifications and increase the risk of death. The aim of this study was to compare the admission CaP between survivors and non survivors and investigate if that could predict the survival outcomes in critically ill non-CKD patients. Methods: Altogether 126 study participants were enrolled which comprised of 3 cohorts: 52 critically ill non CKD patients, 49 CKD patients and 25 healthy subjects. Blood samples were collected within 24 hours of admission and calcium, phosphate, and CaP were estimated. Statistical analysis was performed on SPSS version 25. Results: The admission levels of phosphate, and CaP were significantly higher in non-survivors (p= 0.002 and 0.011). Regression analysis revealed that phosphate (r2=0.170, p= 0.002) and CaP (r2=0.122, p= 0.011) could significantly predict mortality. ROC analysis showed satisfactory performance of admission phosphate and CaP (AUC= 0.719 and 0.621) in classifying patients at risk of mortality. Kaplan-Meier survival analysis showed the lowest survival rates in admission CaP < 22 mg2/dL2 and > 43 mg2/dL2. Conclusion: Abnormal CaP is associated with increased incidence of mortality in critically ill patients and measuring CaP at admission can be a useful tool to predict the survival outcomes.
650			_aSerum.
650			_aCalcium phosphate.
650			_aPredictor of mortality.
650			_aHospitalized patients.
856			_yhttps://www.nhrc.gov.np/
942			_2NLM _cTR
999			_c3301 _d3301