Efficacy of curcumin as an adjunct to intralesional dexamethasone with hyaluronidase in the treatment of oral submucous fibrosis: a randomized controlled trial.
ABSTRACT: Background and Objectives: Oral Submucous Fibrosis (OSF) is a potentially malignant disorder caused by areca nut chewing characterized by restricted mouth opening, burning sensation and stiffness and blanching of oral mucosa. Curcumin, a polyphenol compound present in turmeric extract...
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| Format: | Livre |
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c2019.
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| Résumé: | ABSTRACT: Background and Objectives: Oral Submucous Fibrosis (OSF) is a potentially malignant disorder caused by areca nut chewing characterized by restricted mouth opening, burning sensation and stiffness and blanching of oral mucosa. Curcumin, a polyphenol compound present in turmeric extracted from rhizomes of Curcuma Longa is known to have anti-oxidant, anti-inflammatory, anti-carcinogenic and anti fibrinolytic property. The aim of this study was to determine the efficacy of curcumin as an adjunct to intralesional dexamethasone and hyaluronidase in the treatment of OSF. Methods: A double blinded, two armed, parallel randomized controlled trial was conducted among thirty four patients with clinically diagnosed OSF. Patients were randomized into two groups. Both the groups received baseline treatment of intralesional dexamethasone and hyaluronidase for 6 weeks. An adjunct of curcumin (2gm/day) was provided to Group A (Test) and Group B (Control) received placebo for 6 weeks. All the patients were advised with mouth opening exercise for 12 weeks. Interincisal mouth opening, tongue protrusion, cheek flexibility and visual analogue scale (VAS) scoring of burning sensation of oral mucosa was recorded at baseline, 6, 8 and 12 weeks follow-up. Results: On comparing the 6 weeks and baseline values, the mean difference in mouth opening in Group A and B was 8.82±1.33 mm and 5.53±1.17 mm respectively. The mean difference in cheek flexibility in Group A and B was 2.94±1.02 mm and 1.94±1.24 mm respectively. The mean difference in tongue protrusion in Group A and B was 6.23±1.48 and 3.65±1.37 mm respectively. All the differences were statistically significant. There was 100% improvement in VAS score of burning sensation in both the groups. Conclusion: Curcumin as an adjunct to intralesional dexamethasone with hyaluronidase is efficacious in treatment of OSF in terms of improvement in interincisal opening, cheek flexibility and tongue protrusion. Key words: Oral submucous fibrosis (OSF), Treatment, Curcumin, Efficacy |
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| Description: | Thesis Report. |
| Description matérielle: | 69p. |