To investigate the efficacy and safety of diacerein in the management of knee osteoarthritis with reference to its conventional management: An analytical cohort study.
ABSTRACT: Introduction: Designated as a "priority disease" by WHO, Osteoarthritis (OA) is the most common chronic rheumatic disease. Providing a proper treatment for OA is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disea...
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| Format: | Book |
| Language: | English |
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c2022.
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| Online Access: | Visit NHRC Library |
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| Summary: | ABSTRACT: Introduction: Designated as a "priority disease" by WHO, Osteoarthritis (OA) is the most common chronic rheumatic disease. Providing a proper treatment for OA is still a major public health challenge. Diacerein has been proposed as a slow acting, symptom modifying or even disease modifying drug used in OA having a risk-benefit ratio far better than conventionally used drugs. However, the evidence of efficacy and safety of use of Diacerein in OA is yet to be explored. Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis. Methods: This is an analytical cohort study comparing Diacerein with NSAIDs for two months in the management of knee OA. A hundred and five patients were assigned in each group as per the prescription by the clinician. Efficacy was assessed by Lysholm Knee scoring scale, Knee injury and Osteoarthritis Outcome Score (KOOS) - Physical Function Short form. (KOOS-PS) and Western Ontario and Mcmaster Universities Osteoarthritis Index (WOMAC). Results: After two months of treatment, the post-treatment scores were significantly superior to the baseline scores in both the treatment groups (p<0.001). There were no significant differences among the post-treatment scores in two different treatment groups (p>0.05). Discoloration of urine and gastritis were the frequently reported adverse effects in Diacerin treatment group and NSAIDs treatment group respectively. Conclusion: Our findings have shown Diacerein is as effective as NSAIDs in treating knee OA patients. Diacerein was generally well tolerated, with a good safety profile. These findings indicate the need for further studies with experimental study design in larger sacle. Key Words: Diacerein, Efficacy, Knee Osteoarthritis, NSAIDs, Safety. |
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| Item Description: | Research Report. |
| Physical Description: | 56p. |