The Genetics and Physiology of Altitude Illness
Background: The purpose of this study was to look for potential genetic and physiological risk factors for acute mountain sickness. Methods During the 2012 Janai Purnima festival, 538 subjects were recruited in Dhunche (1950 m) before ascending to Gosainkunda. Through interviews, subjects provided d...
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| Format: | Technical Report |
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| Language: | en_US |
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2016
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| Online Access: | http://103.69.126.140:8080/handle/123456789/161 |
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oai:103.69.126.140:123456789-1612022-11-08T10:29:26Z The Genetics and Physiology of Altitude Illness Communicable/Infectious diseases acute mountain sickness genetic and physiological risk factors incidence predictor Background: The purpose of this study was to look for potential genetic and physiological risk factors for acute mountain sickness. Methods During the 2012 Janai Purnima festival, 538 subjects were recruited in Dhunche (1950 m) before ascending to Gosainkunda. Through interviews, subjects provided demographic information, ratings of AMS symptoms (Lake Louise Scores; LLS), ascent profiles, and strategies for prophylaxis. Results: In total, 491 subjects (91% follow-up rate) who were assessed upon arrival at Gosainkunda, the incidence of AMS was 34.0%. AMS was more common in females than in males (RR = 1.57; 95% CI = 1.23, 2.00), and the AMS incidence was greater in subjects .35 years compared to subjects #35 years (RR = 1.63; 95% CI = 1.36, 1.95). There was a greater incidence of AMS in subjects who chose to use garlic as a prophylactic compared to those who did not (RR=1.69; 95% CI=1.26, 2.28). Although the LLS of brothers had a moderate correlation (intraclass correlation = 0.40, p = 0.023), sibling AMS status was a weak predictor of AMS. Conclusions: There were no adverse events reported in any of the research participants. Keywords: acute mountain sickness; genetic and physiological risk factors; incidence; predictor. 2016-11-11T00:16:07Z 2022-11-08T10:10:43Z 2016-11-11T00:16:07Z 2022-11-08T10:10:43Z 2012 Technical Report http://103.69.126.140:8080/handle/123456789/161 en_US application/vnd.openxmlformats-officedocument.wordprocessingml.document application/vnd.openxmlformats-officedocument.wordprocessingml.document |
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acute mountain sickness genetic and physiological risk factors incidence predictor |
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acute mountain sickness genetic and physiological risk factors incidence predictor The Genetics and Physiology of Altitude Illness |
| description |
Background:
The purpose of this study was to look for potential genetic and physiological risk factors for acute mountain sickness.
Methods
During the 2012 Janai Purnima festival, 538 subjects were recruited in Dhunche (1950 m) before ascending to Gosainkunda. Through interviews, subjects provided demographic information, ratings of AMS symptoms (Lake Louise Scores; LLS), ascent profiles, and strategies for prophylaxis.
Results:
In total, 491 subjects (91% follow-up rate) who were assessed upon arrival at Gosainkunda, the incidence of AMS was 34.0%. AMS was more common in females than in males (RR = 1.57; 95% CI = 1.23, 2.00), and the AMS incidence was greater in subjects .35 years compared to subjects #35 years (RR = 1.63; 95% CI = 1.36, 1.95). There was a greater incidence of AMS in subjects who chose to use garlic as a prophylactic compared to those who did not (RR=1.69; 95% CI=1.26, 2.28). Although the LLS of brothers had a moderate correlation (intraclass correlation = 0.40, p = 0.023), sibling AMS status was a weak predictor of AMS.
Conclusions:
There were no adverse events reported in any of the research participants.
Keywords: acute mountain sickness; genetic and physiological risk factors; incidence; predictor. |
| format |
Technical Report |
| title |
The Genetics and Physiology of Altitude Illness |
| title_short |
The Genetics and Physiology of Altitude Illness |
| title_full |
The Genetics and Physiology of Altitude Illness |
| title_fullStr |
The Genetics and Physiology of Altitude Illness |
| title_full_unstemmed |
The Genetics and Physiology of Altitude Illness |
| title_sort |
genetics and physiology of altitude illness |
| publishDate |
2016 |
| url |
http://103.69.126.140:8080/handle/123456789/161 |
| _version_ |
1761500876879429632 |