Progesterone for Prevention of Recurrent Preterm Labor after Threatened Preterm Labor - A Randomized Controlled Trial
Background: Preterm birth is the major cause of neonatal mortality and morbidity. In addition, prematurity is strongly associated with long-term developmental disabilities, accounting for 1 in 5 children with mental retardation, 1 in 3 children with vision impairment, and almost half of children wit...
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| Format: | Technical Report |
| Language: | en_US |
| Published: |
2016
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| Subjects: | |
| Online Access: | http://103.69.126.140:8080/handle/123456789/221 |
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| Summary: | Background:
Preterm birth is the major cause of neonatal mortality and morbidity. In addition, prematurity is strongly associated with long-term developmental disabilities, accounting for 1 in 5 children with mental retardation, 1 in 3 children with vision impairment, and almost half of children with cerebral palsy. So, prevention of preterm birth is a public health priority.
Methods:
A randomized controlled trial was undertaken in BP Koirala Institute of Health Sciences, where 60 patients were randomized into group 1 (n=29, weekly intramuscular Progesterone) and group 2 (n=31, no treatment) after the arrest of preterm labor with tocolysis. Their latency period till delivery and recurrence of preterm labor and neonatal outcomes were compared
Results:
There was significant reduction in recurrence of preterm labor and increase in latency period in progesterone group. However neonatal outcomes were similar.
Conclusions:
Progesterone is useful in reducing the recurrence of preterm labor in a patient who had preterm labor.
Keywords: preterm labor; progesterone; tocolysis. |
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