Rapid Non-Invasive Diagnosis of Kala-azar

Background: Kala-azar is endemic throughout central and eastern terai region of Nepal bordering the Indian state of Bihar. Lack of knowledge, unavailable simple and reliable diagnostic test and poverty-all contribute to late diagnosis and institution of an effective chemotherapy; thereby maintaining...

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Main Authors:	Gyawali, K, Thapa, S, Devkota, B, Yadav, CS
Format:	Technical Report
Language:	en_US
Published:	2016
Subjects:	endemic Kala-azar positive predictive value rK-39 Leishmania dipstick sensitivity
Online Access:	http://103.69.126.140:8080/handle/123456789/71
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spelling	oai:103.69.126.140:123456789-712022-11-08T10:29:21Z Rapid Non-Invasive Diagnosis of Kala-azar Communicable/Infectious diseases Gyawali, K Thapa, S Devkota, B Yadav, CS endemic Kala-azar positive predictive value rK-39 Leishmania dipstick sensitivity Background: Kala-azar is endemic throughout central and eastern terai region of Nepal bordering the Indian state of Bihar. Lack of knowledge, unavailable simple and reliable diagnostic test and poverty-all contribute to late diagnosis and institution of an effective chemotherapy; thereby maintaining the potential human reservoir at high level in the community. Since invasive diagnostic method is an unacceptable test of choice in the endemic region, an alternative technique is a dire necessity. The present study evaluated recombinant K-39 Leishmania test with splenic aspirate in hospitalized Kala-azar patients. Methods: This was a retrospective review of hospital case record of Kala-azar patients admitted during the months of Poush- Chaitra 2057. All hospital case notes of the 4 months with the diagnosis of Kala-azar were screened. Shukraraj Tropical and Infectious Disease Hospital, Teku was taken as the study area. Results: The rK-39 Leishmania dipstick achieved a high sensitivity (96%) and high positive value (95%). The dipstick is a simple, reliable and a robust technique. Conclusions: The rK-39 Leishmania dipstick is an acceptable test of choice in the diagnosis of Kala-azar and may be of great utility especially in the endemic districts where invasive methods are neither applicable nor appropriate. Keywords: endemic; Kala-azar; positive predictive value; rK-39 Leishmania dipstick; sensitivity. 2016-10-27T08:19:35Z 2022-11-08T10:10:12Z 2016-10-27T08:19:35Z 2022-11-08T10:10:12Z 2001 Technical Report http://103.69.126.140:8080/handle/123456789/71 en_US application/vnd.openxmlformats-officedocument.wordprocessingml.document
institution	My University
collection	DSpace
language	en_US
topic	endemic Kala-azar positive predictive value rK-39 Leishmania dipstick sensitivity
spellingShingle	endemic Kala-azar positive predictive value rK-39 Leishmania dipstick sensitivity Gyawali, K Thapa, S Devkota, B Yadav, CS Rapid Non-Invasive Diagnosis of Kala-azar
description	Background: Kala-azar is endemic throughout central and eastern terai region of Nepal bordering the Indian state of Bihar. Lack of knowledge, unavailable simple and reliable diagnostic test and poverty-all contribute to late diagnosis and institution of an effective chemotherapy; thereby maintaining the potential human reservoir at high level in the community. Since invasive diagnostic method is an unacceptable test of choice in the endemic region, an alternative technique is a dire necessity. The present study evaluated recombinant K-39 Leishmania test with splenic aspirate in hospitalized Kala-azar patients. Methods: This was a retrospective review of hospital case record of Kala-azar patients admitted during the months of Poush- Chaitra 2057. All hospital case notes of the 4 months with the diagnosis of Kala-azar were screened. Shukraraj Tropical and Infectious Disease Hospital, Teku was taken as the study area. Results: The rK-39 Leishmania dipstick achieved a high sensitivity (96%) and high positive value (95%). The dipstick is a simple, reliable and a robust technique. Conclusions: The rK-39 Leishmania dipstick is an acceptable test of choice in the diagnosis of Kala-azar and may be of great utility especially in the endemic districts where invasive methods are neither applicable nor appropriate. Keywords: endemic; Kala-azar; positive predictive value; rK-39 Leishmania dipstick; sensitivity.
format	Technical Report
author	Gyawali, K Thapa, S Devkota, B Yadav, CS
author_facet	Gyawali, K Thapa, S Devkota, B Yadav, CS
author_sort	Gyawali, K
title	Rapid Non-Invasive Diagnosis of Kala-azar
title_short	Rapid Non-Invasive Diagnosis of Kala-azar
title_full	Rapid Non-Invasive Diagnosis of Kala-azar
title_fullStr	Rapid Non-Invasive Diagnosis of Kala-azar
title_full_unstemmed	Rapid Non-Invasive Diagnosis of Kala-azar
title_sort	rapid non-invasive diagnosis of kala-azar
publishDate	2016
url	http://103.69.126.140:8080/handle/123456789/71
work_keys_str_mv	AT gyawalik rapidnoninvasivediagnosisofkalaazar AT thapas rapidnoninvasivediagnosisofkalaazar AT devkotab rapidnoninvasivediagnosisofkalaazar AT yadavcs rapidnoninvasivediagnosisofkalaazar AT gyawalik communicableinfectiousdiseases AT thapas communicableinfectiousdiseases AT devkotab communicableinfectiousdiseases AT yadavcs communicableinfectiousdiseases
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Rapid Non-Invasive Diagnosis of Kala-azar

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