Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial

Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial

Background Because treatment with third-generation cephalosporins is associated with slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin is associated with rapid fever clearance and low relapse burden, we postulated that gatifloxacin would b...

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Main Authors: Arjyal, Amit, Basnyat, Buddha, Nhan, Ho Thi, Koirala, Samir, Giri, Abhishek, Joshi, Niva, Shakya, Mila, Pathak, Kamal Raj, Mahat, Saruna Pathak, Prajapati, Shanti Pradhan, Adhikari, Nabin, Thapa, Rajkumar, Merson, Laura, Gajurel, Damodar, Lamsal, Kamal, Lamsal, Dinesh, Yadav, Bharat Kumar, Shah, Ganesh, Shrestha, Poojan, Dongol, Sabina, Karkey, Abhilasha, Thompson, Corinne N, Thieu, Nga Tran Vu, Thanh, Duy Pham, Baker, Stephen, Thwaites, Guy E, Wolbers, Marcel, Dolecek, Christiane
Format: Technical Report
Language:en_US
Published: Lancet Infect Dis 2016 2016
Subjects:
Gatifloxacin versus
Enteric Fever
Nepal
Online Access:http://103.69.126.140:8080/handle/123456789/818
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spelling oai:103.69.126.140:123456789-8182022-11-09T06:51:38Z Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial Arjyal, Amit Basnyat, Buddha Nhan, Ho Thi Koirala, Samir Giri, Abhishek Joshi, Niva Shakya, Mila Pathak, Kamal Raj Mahat, Saruna Pathak Prajapati, Shanti Pradhan Adhikari, Nabin Thapa, Rajkumar Merson, Laura Gajurel, Damodar Lamsal, Kamal Lamsal, Dinesh Yadav, Bharat Kumar Shah, Ganesh Shrestha, Poojan Dongol, Sabina Karkey, Abhilasha Thompson, Corinne N Thieu, Nga Tran Vu Thanh, Duy Pham Baker, Stephen Thwaites, Guy E Wolbers, Marcel Dolecek, Christiane Gatifloxacin versus Enteric Fever Nepal Background Because treatment with third-generation cephalosporins is associated with slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin is associated with rapid fever clearance and low relapse burden, we postulated that gatifloxacin would be superior to the cephalosporin ceftriaxone in treating enteric fever. 2016-01-28T20:37:59Z 2022-11-08T10:23:58Z 2016-01-28T20:37:59Z 2022-11-08T10:23:58Z 2016-01-16 Technical Report http://103.69.126.140:8080/handle/123456789/818 en_US application/pdf Lancet Infect Dis 2016
institution My University
collection DSpace
language en_US
topic Gatifloxacin versus
Enteric Fever
Nepal
spellingShingle Gatifloxacin versus
Enteric Fever
Nepal
Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne N
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane
Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
description Background Because treatment with third-generation cephalosporins is associated with slow clinical improvement and high relapse burden for enteric fever, whereas the fluoroquinolone gatifloxacin is associated with rapid fever clearance and low relapse burden, we postulated that gatifloxacin would be superior to the cephalosporin ceftriaxone in treating enteric fever.
format Technical Report
author Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne N
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane
author_facet Arjyal, Amit
Basnyat, Buddha
Nhan, Ho Thi
Koirala, Samir
Giri, Abhishek
Joshi, Niva
Shakya, Mila
Pathak, Kamal Raj
Mahat, Saruna Pathak
Prajapati, Shanti Pradhan
Adhikari, Nabin
Thapa, Rajkumar
Merson, Laura
Gajurel, Damodar
Lamsal, Kamal
Lamsal, Dinesh
Yadav, Bharat Kumar
Shah, Ganesh
Shrestha, Poojan
Dongol, Sabina
Karkey, Abhilasha
Thompson, Corinne N
Thieu, Nga Tran Vu
Thanh, Duy Pham
Baker, Stephen
Thwaites, Guy E
Wolbers, Marcel
Dolecek, Christiane
author_sort Arjyal, Amit
title Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
title_short Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
title_full Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
title_fullStr Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
title_full_unstemmed Gatifloxacin versus ceftriaxone for uncomplicated enteric fever in Nepal: an open-label, two-centre, randomized controlled trial
title_sort gatifloxacin versus ceftriaxone for uncomplicated enteric fever in nepal: an open-label, two-centre, randomized controlled trial
publisher Lancet Infect Dis 2016
publishDate 2016
url http://103.69.126.140:8080/handle/123456789/818
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