In vitro evaluation of different brands of metformin Hydrochloride tablets available in Pokhara Valley. (Record no. 2817)
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| fixed length control field | 02451nam a22002777a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230917121040.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191111b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Description conventions | NLM |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | THS-00254 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Paudel,Rupesh. |
| 9 (RLIN) | 2697 |
| 245 ## - TITLE STATEMENT | |
| Title | In vitro evaluation of different brands of metformin Hydrochloride tablets available in Pokhara Valley. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | c2011. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | ix,42p. |
| 500 ## - GENERAL NOTE | |
| General note | Thesis Report. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT: In Nepal, 36 different brands of Metformin Hydrochloride tablets of 500 mg (milligram) are registered in Department of Drug Administration (DDA), Nepal including products from World Health Organization recommended Good Manufacturing Practice (WHOGMP) certified and non-GMP certified Nepalese pharmaceutical industries as well as imported brands. Prescribers are often in difficult situation to choose the ideal brand among various seemingly equivalent brands. Previous studies in Nepal on Albendazole and Pantoprazole indicated the risk of substandard drugs which evoked the necessity of pharmaceutical evaluation of different marketed brands. On the other side, India one of the major source for import of pharmaceutical products, claims the prevalence of substandard medicine in major Indian markets. The lifelong use of metformin, possible price variation, and risk of substandard drugs requires the detail study regarding the quality control parameter. Eight different brands including 3 Nepalese GMP certified, 1 Nepalese non GMP certified, 4 imported brands were taken under study. Pharmacopoeial quality control parameter viz. friability, weight and weight variation, dissolution and assay were carried out as per Indian Pharmacopoeia 1996 amendment II. Similarly non pharmacopoeial analysis such as hardness was analyzed. Thus, this study was conducted to evaluate the different brands of metformin in Pokhara valley in vitro. All the data are represented as Mean ± SD. The statistical analysis were done using SPSS version 17 for analysis of variance (ANOVA) at p value 0.05. Key words: Metformin, in vitro, pharmacopoeial, evaluation |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Metformin. |
| 9 (RLIN) | 2698 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | in vitro. |
| 9 (RLIN) | 2699 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | pharmacopoeial. |
| 9 (RLIN) | 2700 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | evaluation. |
| 9 (RLIN) | 1307 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Palikhe,Alisha. |
| 9 (RLIN) | 2701 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Dhungana,Asha. |
| 9 (RLIN) | 2702 |
| 700 ## - ADDED ENTRY--PERSONAL NAME | |
| Personal name | Karki,Sandeep. |
| 9 (RLIN) | 2703 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://nhrc.gov.np/contact/">http://nhrc.gov.np/contact/</a> |
| Link text | Visit NHRC Library |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | National Library of Medicine |
| Koha item type | Thesis Report |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
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| National Library of Medicine | Nepal Health Research Council | Nepal Health Research Council | Reference | 11/11/2019 | THS00254/PAU/2011 | THS-00254 | 11/11/2019 | 11/11/2019 | Thesis Report |