Diagnostic accuracy of USG-guided fine needle aspiration cytology (FNAC) and genexpert in the diagnosis of tuberculosis in cervical lymphadenopathy patients (Record no. 3482)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02780nam a22002417a 4500 |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20251007140520.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 251007b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Description conventions | NLM |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | WI 141.5.L5 |
| Item number | 00770 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | KC, Crystal Dr. |
| 245 ## - TITLE STATEMENT | |
| Title | Diagnostic accuracy of USG-guided fine needle aspiration cytology (FNAC) and genexpert in the diagnosis of tuberculosis in cervical lymphadenopathy patients |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Place of publication, distribution, etc. | Kathmandu, Nepal ; |
| Name of publisher, distributor, etc. | Kathmandu University & Nepal Health Research Council (NHRC) ; |
| Date of publication, distribution, etc. | 2025. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | 47p. |
| 500 ## - GENERAL NOTE | |
| General note | In partial fulfilment of the requirements for the degree of Master in Medical Research. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly common worldwide, especially in South Asia. Liver fibrosis is the most critical factor influencing long- term outcomes in MASLD. FibroScan is a trusted non-invasive method to assess fibrosis. Its high cost and limited availability in settings like Nepal make simpler alternatives necessary. The Fibrosis-4 (FIB-4) index, based on routine lab tests, is one such option-but its accuracy in the Nepalese MASLD population remains unclear. This study aimed to assess the diagnostic accuracy of the FIB-4 index in detecting hepatic fibrosis in MASLD compared to FibroScan at a tertiary care center in Nepal.<br/>Materials and methods: A cross-sectional diagnostic accuracy study was carried out at Nobel Medical College in Biratnagar, involving 135 adult patients diagnosed with MASLD. FIB-4 scores were calculated and compared against liver stiffness measurements (LSM) obtained via FibroScan. We evaluated the sensitivity, specificity, and overall diagnostic accuracy of FIB-4 at different cutoff values.<br/>Results: FIB-4 showed good diagnostic performance: AUROC 0.852 for significant fibrosis (≥7 kPa) and 0.868 for advanced fibrosis (29.7 kPa). At a cut-off above 1.3, it identified significant fibrosis (LSM 27 kPa) with 86.6% sensitivity and 66.0% specificity. A higher cut-off (>2.67) yielded excellent specificity (92.5%) for confirming fibrosis, though with lower sensitivity. For advanced fibrosis (LSM 29.7 kPa), FIB-4 achieved 80.0% sensitivity and 95.0% specificity. FIB-4 scores also rose progressively with the fibrosis stage and had a strong correlation with FibroScan values (r = 0.776).<br/>Conclusion: FIB-4 is a reliable, affordable tool for assessing liver fibrosis in MASLD and may serve as a practical alternative where FibroScan is not accessible. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Extrapulmonary tuberculosis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Lymphadenitis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Sensitivity and spedificity. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Tuberculosis. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Nepal. |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Link text | https://nhrc.gov.np/contact |
| Public note | Visit NHRC Library |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | National Library of Medicine |
| Koha item type | Thesis Report |
| Call number prefix | THS00770-KC-2025. |
| Suppress in OPAC | Yes |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Copy number | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | Nepal Health Research Council | Nepal Health Research Council | Thesis Cart | 10/07/2025 | WI 141.5.L5/THS00770/KC/2025 | THS00770 | 10/07/2025 | 1 | 10/07/2025 | Thesis Report |