Antiulcerogenic activity of avipattikar churna on peptic ulcer in experimental rats. (Record no. 724)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 02658 a2200253 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230917121247.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 230917b |||||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Description conventions | NLM |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | THS-00253 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Gautam, Jaya |
| -- | Adhikari, Rashmi |
| -- | Lamsal, Reshma |
| -- | Ghimire, Saurav |
| -- | Lamichane, Shreekrishna |
| 9 (RLIN) | 1899 |
| 245 ## - TITLE STATEMENT | |
| Title | Antiulcerogenic activity of avipattikar churna on peptic ulcer in experimental rats. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | c2011. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | vii, 52p. : |
| 500 ## - GENERAL NOTE | |
| General note | Thesis Report. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT: Peptic ulcer is an excoriated area of stomach or intestinal mucosa, resulting due to imbalance between the aggressive factors (acid, pepsin, bile, H. pylori) and the defensive factors (gastric mucous, bicarbonate secretions, prostaglandin, nitric oxide, innate resistance of the mucosal cells. In traditional medicine, many medicinal plants are combined and administered to treat the peptic ulcer as they are rich in active principles and antioxidants. The marketed formulation Avipattikar churna composed of fourteen ingredients which has been used for the treatment of G.I. disorders due to synergistic action. The antiulcerogenic activity of Avipattikar churna was evaluated in pyloric ligated model in rats. Twenty four rats were divided in four groups each containing six rats. Group I, II, III, IV were served as ulcer control, churna low dose (500 mg/kg), churna high dose (750mg/kg) and ranitidine (25mg/kg) group respectively. The gastric contents were collected and evaluated for volume of gastric content, pH, volume of NaOH consumed, acidity, length of ulcer, number of ulcer, gastric irritancy index and curative ratio. In the present study Avipattikar churna was found to have significant antiulcer activity with reference drug ranitidine in pyloric ligation induced gastric ulcers in experimental rats. The test drug reduced the gastric juice volume, acidity, ulcer index and increased the pH of the gastric content. The results were analysed using One-Way ANOVA followed by Dunnett test considering p < 0.01 as level of significance. There were no significant differences on the curative ratio among the treated group which means churna can heal the ulcer in the same extent as ranitidine does. The present finding demonstrated that Avipattikar churna has potent antisecretory and antiulcer effect and justify the usage of this herb to treat peptic ulcer. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Eng. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Antiulcerogenic. |
| 9 (RLIN) | 2704 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Avipattikar churna. |
| 9 (RLIN) | 2705 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Peptic Ulcer. |
| 9 (RLIN) | 2706 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Experimental rats. |
| 9 (RLIN) | 2707 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://nhrc.gov.np/contact/">http://nhrc.gov.np/contact/</a> |
| Link text | Visit NHRC Library |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | National Library of Medicine |
| Koha item type | Thesis Report |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | Nepal Health Research Council | Nepal Health Research Council | Reference | 07/29/2012 | THS00253/GAU/2011 | THS-00253 | 07/29/2012 | 07/29/2012 | Thesis Report |