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Formulation and evaluation of mucoadhesive buccal tablets of aceclofenac.

By:

Dahal, Aashma

Contributor(s):

Material type: Text

TextPublication details: c2014.Description: xi, 46pSubject(s):

NLM classification:

THS-00407

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Summary: ABSTRACT: Introduction : Buccal mucoadhesive dosage forms of Aceclofenac are designed to enable prolonged retention at the site of application, providing a controlled rate of drug release and high drug flux at the site of absorptive mucosa for improved therapeutic outcome. It can also help to overcome the enzymatic degradation of the drug by GI enzymes. In addition, the first pass effects can also be avoided. Objective: The objective of our research project was to formulate mucoadhesive buccal tablets of Aceclofenac and carry out the evaluation studies. Our study was also focused on the mucoadhesive behavior and other characteristics of the polymers used. Methods: Twelve different batches of Aceclofenac tablets (B1-B12) were formulated by direct compression method using three different polymers Carbopol 934p, Hydroxypropy1 Methylcellulose(HPMC) and Sodium CMC at different concentrations. The compressed tablets were evaluated for their hardness, friability, swelling index, surface pH, ex vivo mucoadhesion and dissolution characteristics. Results: The batches were evaluated for physical parameters like weight variation, surface pH, hardness, friability, thickness which were within the acceptable limit of India pharmacopoeia 2007. The swelling index was evaluated for all batches and found to be highest in B8 (S.1. = 450.19%) and lowest in BI (S.1 = 112.93%) at 8 hours. The surface pH of all batches was found to be in between 6.72 to 6.96. The drug content evaluation showed that all batches remained within the limit stated by India pharmacopoeia i.e. from 95% to 105%. Different batches of tablet showed different dissolution profiles where batch B10 showed the maximum release of 109.41% in 6 hours and batch B3 showed the least release of 44.82% in 12 hours. The mucoadhesive strengths varied with the change in polymer concentrations mainly Carbopol 934p. Batch B7 and B10-B12 showed higher mucoadhesion than other. The FTIR studies showed that the drug and polymer used were compatible with each other. Conclusion: The results led to the conclusion that mucoadhesive property depends not only on the concentration but also the behavior of the polymers used. Keywords: Aceclofenac, Buccal tablets, First pass effects, Mucoadhesion, swelling index

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Item type	Current library	Call number	Status	Date due	Barcode
Thesis Report	Nepal Health Research Council	THS00407/DAH/2014 (Browse shelf(Opens below))	Available		THS-00407

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Thesis Report.

ABSTRACT:

Introduction : Buccal mucoadhesive dosage forms of Aceclofenac are designed to enable prolonged retention at the site of application, providing a controlled rate of drug release and high drug flux at the site of absorptive mucosa for improved therapeutic outcome. It can also help to overcome the enzymatic degradation of the drug by GI enzymes. In addition, the first pass effects can also be avoided.

Objective: The objective of our research project was to formulate mucoadhesive buccal tablets of Aceclofenac and carry out the evaluation studies. Our study was also focused on the mucoadhesive behavior and other characteristics of the polymers used. Methods: Twelve different batches of Aceclofenac tablets (B1-B12) were formulated by direct compression method using three different polymers Carbopol 934p, Hydroxypropy1 Methylcellulose(HPMC) and Sodium CMC at different concentrations. The compressed tablets were evaluated for their hardness, friability, swelling index, surface pH, ex vivo mucoadhesion and dissolution characteristics.

Results: The batches were evaluated for physical parameters like weight variation, surface pH, hardness, friability, thickness which were within the acceptable limit of India pharmacopoeia 2007. The swelling index was evaluated for all batches and found to be highest in B8 (S.1. = 450.19%) and lowest in BI (S.1 = 112.93%) at 8 hours. The surface pH of all batches was found to be in between 6.72 to 6.96. The drug content evaluation showed that all batches remained within the limit stated by India pharmacopoeia i.e. from 95% to 105%. Different batches of tablet showed different dissolution profiles where batch B10 showed the maximum release of 109.41% in 6 hours and batch B3 showed the least release of 44.82% in 12 hours. The mucoadhesive strengths varied with the change in polymer concentrations mainly Carbopol 934p. Batch B7 and B10-B12 showed higher mucoadhesion than other. The FTIR studies showed that the drug and polymer used were compatible with each other.

Conclusion: The results led to the conclusion that mucoadhesive property depends not only on the concentration but also the behavior of the polymers used.

Keywords: Aceclofenac, Buccal tablets, First pass effects, Mucoadhesion, swelling index

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