Nepal burden of disease 2017: A country reported based on the global burden of disease 2017 study.

Research Report.

SUMMARY: The Global Burden of Disease (GBD) study is a systematic effort to quantify the comparative magnitude of health loss due to diseases, injuries, and risk factors by age, sex, and geographies for specific points in time. It provides a comprehensive picture of total health loss due to diseases, injuries, and death. IHME has recently produced GBD 2017 estimates, which highlight Nepal's health performance in terms of mortality, morbidity, and overall disease burden. These have been extracted to produce this Nepal Burden of Disease (NBoD) Study 2017 Report. The GBD, and thus the NBoD Study 2017, measures overall mortality, causes of mortality, causes of morbidity, and risk factors. Overall mortality is expressed in the form of number of deaths due to diseases and injuries and their rates per 100,000 population. Causes of mortality are captured through years of life lost (YLLs), which give years of life lost due to premature death from a disease or injury. Years lived with disability (YLDs) measure causes of morbidity; they are used to indicate the number of years lived with disability due to a nonfatal disease or injury. YLLs and YLDs together give the overall burden of disease or injury. It is expressed in the form of disability adjusted life years (DALYs). Results described in the NBoD 2017 report reveal that females are expected to live longer (73.3 years) than males (68.7 years). Life expectancy increased from 59 to 73 years for females, and 58 to 69 years for males, between 1990 and 2017. However, not all these additional years gained will be healthy ones. Females are expected to live 62 years of healthy life, while males will live 60 years of healthy life. This discrepancy between life expectancy and healthy life expectancy is due to years of healthy life lost as a result of ill health and disability. A total of 182,751 deaths are estimated in Nepal for the year 2017. Non-communicable diseases (NCDs) are the leading causes of death - twothirds (66%) of deaths are due to NCDs, with an additional 9% due to injuries. The remaining 25% are due to communicable, maternal, neonatal, and nutritional (CMNN) diseases. Ischemic heart disease (16.4% of total deaths), chronic obstructive pulmonary disease (COPD) (9.8% of total deaths), diarrheal diseases (5.6% of total deaths), lower respiratory infections (5.1% of total deaths), and intracerebral hemorrhage (3.8% of total deaths), were the top five causes of death in 2017. The rise of NCDs is partly due to the changing age structure and lifestyle changes such as increasing sedentary behavior, tobacco use, changes in eating habits, and harmful use of alcohol. Similarly, out of the total (5,850,044) YLLs due to premature death (people dying earlier than their potential life expectancy), 49% are due to NCDs, 39% due to CMNN diseases and the remaining 12% due to injuries. The top five causes (all ages both sexes) of YLLs are ischemic heart disease (11.3% of total YLLs), lower respiratory infections (7.9% of total YLLs), neonatal encephalopathy (5.7% of total YLLs), COPD (5.5% of total YLLs), and diarrheal diseases (4.5% of total YLLs). The leading causes of morbidity (YLDs) are low back pain, migraine, COPD, and other musculoskeletal disorders. Approximately 59% of disease burden (including premature death and disability - DALYs) in 2017 is due to NCDs, 31% due to CMNN diseases, and 10% due to injuries. Ischemic heart disease (7.6% of DALYs), COPD (5.4% of DALYs), and lower respiratory infections (5.2% of DALYs) are the top three disease conditions causing most of the disease burden in 2017. The findings further reveal that short gestation for birth weight (7.5% of total DALYs), high systolic blood pressure (6.7% of total DALYs), smoking (6.5% of total DALYs), high blood glucose level (5.5% of total DALYs), and low birth weight for gestation (4.7% of total DALYs) are the top five risk factors driving death and disability in Nepal. From the results presented in the NBoD 2017 report, NCDs are increasingly becoming a major public health issue. Notably, ischemic heart disease and COPD are top causes contributing significantly to the burden of disease (BoD). Maternal and child health outcomes are improving but should not be neglected as there is still much progress to be made. Notable risk factors are metabolic risk factors, ambient and household air pollution, and finally, behavioural risk factors such as smoking. The national BoD profile in 2017 looks vastly different from 1990, or even 2007: these changes must be reviewed and addressed, and Nepal's health policy priorities, strategies, and resource allocations must adapt accordingly.