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Prevalence of sjoren's syndrome in patients with dry eye disease in a tertiary hospital in Nepal.

By:

Chaudhary,Meenu

Material type: Text

TextPublication details: c2022.Description: xv,84pSubject(s):

NLM classification:

RES-01127

Online resources:

http://www.nhrc.gov.np/

Summary: ABSTRACT: Purpose: To study the prevalence of Sjogren’s syndrome in Dry eye patients in a tertiary hospital in Nepal. Methods: 42 patients presenting to the eye out patient department of BPKLCOS & Rheumatology department of TUTH with dry eye symptoms were evaluated for dry eyes for a period of 6 months (Dec 2021- April 2022) . Investigations done included unanaesthetized Schirmer’s test, NIBUT, Ocular staining for cornea and conjunctiva with Fluorescein stain & Lissamine green dye. Blood investigations included ENA profile and minor salivary gland labial biopsy was also done for further confirmation of diagnosis of pSS if ENA profile was negative. Proforma was filled & consent was taken before investigations. Data was entered in SPSS 20 and statistical analysis was done. Results: 42 patients presenting with dry eyes were evaluated which included 31 (73.80%) females and 11 (26.19%) males. The number of patients who had Primary Sjogren’s syndrome in patients with DED was 8 (19.04%) which included 6 (14.28%) females and 2 ( 4.76%) males. Primary SS was more common in the 60-70 years age group in females. Thus, the patients with purely DED were 62%, Prevalence of Primary SS was 19% and secondary SS was 19%. Out of 42 DED patients ENA profile was positive in 8 cases and only one case had positive histopathological finding on Labial salivary gland biopsy to be confirmed as Primary SS. Our study revealed a statistically significant correlation between duration of DED and duration of systemic disease. But, none of the predictors, including the duration of DED and severity of clinical markers of DED were able to predict the diagnosis in our study. Conclusion: Primary & Secondary SS were found to be prevalent in dry eye patients in our hospital and thus, should be the focus of diagnostic evaluations. A minor salivary gland biopsy might be required for a definitive diagnosis in a significant proportion of the patients with SS. Population based studies need to be undertaken.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Research Report	Nepal Health Research Council Reference	Reference	RES01127/CHA/2022 (Browse shelf(Opens below))	Staff Collection		01127

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Research Report.

ABSTRACT:

Purpose: To study the prevalence of Sjogren’s syndrome in Dry eye patients in a tertiary hospital in Nepal.

Methods: 42 patients presenting to the eye out patient department of BPKLCOS & Rheumatology department of TUTH with dry eye symptoms were evaluated for dry eyes for a period of 6 months (Dec 2021- April 2022) . Investigations done included unanaesthetized Schirmer’s test, NIBUT, Ocular staining for cornea and conjunctiva with Fluorescein stain & Lissamine green dye. Blood investigations included ENA profile and minor salivary gland labial biopsy was also done for further confirmation of diagnosis of pSS if ENA profile was negative. Proforma was filled & consent was taken before investigations. Data was entered in SPSS 20 and statistical analysis was done.

Results: 42 patients presenting with dry eyes were evaluated which included 31 (73.80%) females and 11 (26.19%) males. The number of patients who had Primary Sjogren’s syndrome in patients with DED was 8 (19.04%) which included 6 (14.28%) females and 2 ( 4.76%) males. Primary SS was more common in the 60-70 years age group in females. Thus, the patients with purely DED were 62%, Prevalence of Primary SS was 19% and secondary SS was 19%. Out of 42 DED patients ENA profile was positive in 8 cases and only one case had positive histopathological finding on Labial salivary gland biopsy to be confirmed as Primary SS. Our study revealed a statistically significant correlation between duration of DED and duration of systemic disease. But, none of the predictors, including the duration of DED and severity of clinical markers of DED were able to predict the diagnosis in our study.

Conclusion: Primary & Secondary SS were found to be prevalent in dry eye patients in our hospital and thus, should be the focus of diagnostic evaluations. A minor salivary gland biopsy might be required for a definitive diagnosis in a significant proportion of the patients with SS. Population based studies need to be undertaken.

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