Tobotympanic chronic suppurative ottis media: Bacteriology and drug sensitivity.

Thesis Report.

ABSTRACT: The study included 100 patients having CSOM (TT) from whom 112 ear swabs were collected at the ENT of the TU teaching Hospital in Kathmandu. These swabs were tested for bacterial flora =and antibiotic sensitivity pattern. The study included 56 male and 44 female patients. Age of the patients ranged from 8 years to 71 years, the mean age being 23.4 years . The disease was found high in the age group 20 to 25 years. The average duration of discharge was 10.2 years ( ranged from 3 months to 52 years). Of the 115 ear swabs cultured, 100 showed growth. one hundred forty-two micro-organisms were isolated. On gram-staining 112 ear swabs showed organisms while in 3 swabs organisms were not seen in gram-staining nor did the culture reveal any growth. Of the 142 organisms isolated, monobacterial aerobes were 59, mixed aerobes were 37 mixed aerobes and anaerobes were 4. Monobacterial infection was found in 59 ear swabs and polybacterial in 41. The commonest organisms isolated were Staphylococcus aureus (59isolates) followed by Pseudomonas aeruginosa (48isolates). The aerobic organisms isolated were tested for sensitivity to six commonly used drugs viz. amoxicillin, cephalexin, gentamicin, chloramphenicol and ciprofloxacin. Ciprofloxacin was found to be the most effective drug against both gram-positive and gram-negative organisms; amoxicillin was the least sensitive drug. Six isolates of pseudomonas aeruginosa and a single isolate of staphylococcus aureus showed resistance to all the six antibiotic tested. Multiple drug resistance was exhibited by many isolates of Pseudomonas aerugnosa.

Eng.