Seroprevalence of IgM and igG antibodies against the agents of torch infections among the patients visiting om hospital and research center.

Thesis Report.

ABSTRACT: TORCH infection is a serious threat to human health and is a global issue. The primary infection with TORCH in pregnant women can lead to serious complication (fetal loss, malformation, still child birth) which may initially asymptomatic. In the present study, 161suspected patients' (151 females and 10 males) serum samples were examined for the prevalence of anti TORCH IgM and IgG using ELISA technique (GB corp- Taiwan) during 17th July 2009 to 30th March 2010. In the light of investigation of blood samples, anti toxoplasmosis IgG was found in 26.4 %, IgM in 0.6 % and both IgG + IgM in 0.6 %. At the same time, anti Rubella IgG was found out in 59.3 %, IgM in 0.7 % and both IgG + IgM in 0.7 %. Anti CMV IgG was discovered in 32.7 %, IgM in 6 % and both IgG + IgM in 2 %. Moreover, anti HSV-1 IgG was found out in 5.4 %, IgM in 8.7 % and both IgG + IgM in 0 %. Anti HSV-2 IgG positivity in 25.5 %, IgM in 16.8 % and both IgG + IgM in 4 %. Out of 4 infants, 1(25%) was IgM positive. Sex wise analysis showed high prevalence rate in female in comparison to male and prevalence rate was reported highest most commonly in sexually active age group.In conclusion, wide range of population still susceptible to TORCH. High value of immune response to Rubella and HSV-2 was observed in term of IgM and both IgM + IgG, responsible for major cause of congenital problems. Higher prevalence rate was observed in female than male in child bearing age. So, Health education concerning the preventive measures against TORCH is needed.

Eng.