Comparison of international ovarian tumor analysis-simple rules (IOTA-SR) with risk of malignancy index IV (RMI IV) to predict ovarian cancer
Material type:
TextPublication details: Kathmandu, Nepal ; Kathmandu University & Nepal Health Research Council (NHRC) ; 2025.Description: 80pSubject(s): NLM classification: - WP 322
| Item type | Current library | Call number | Status | Barcode | |
|---|---|---|---|---|---|
Thesis Report
|
Nepal Health Research Council Thesis Cart | WP 322/THS00764/YAD/2025 (Browse shelf(Opens below)) | Available | THS00764 |
In partial fulfilment of the requirements for the degree of Master in Medical Research.
Aim
To compare the diagnostic accuracy of International Ovarian Tumor Analysis (IOTA) simple rules and risk of malignancy index (RMI) IV scoring to differentiate between benign and malignant adnexal masses pre-operatively.
Methods
An observational analytical study carried out to compare two cancer prediction tools among the ovarian tumor patients undergoing surgery in the Department of Obstetrics and Gynecology at Nobel Medical College, Biratnagar in the year 2024 and 2025. The diagnostic accuracy of RMI IV and IOTA SR was compared using SPSS version 16. Histopathology was the gold standard for the final diagnosis. Ethical approval was taken from the Institution Review Committee of the college.
Results
Out of a total 52 cases, 20 cases were classified as malignant tumors by IOTA simple rules that were confirmed by histopathology in only 17 cases. 32 cases predicted by IOTA SR was confirmed to be benign in 31 cases reporting Sensitivity of IOTA SR to be 94.4%, specificity of 94.2%, Positive predictive value of 89.5%, negative predictive value of 96.9% and Diagnostic accuracy of 94.23%. On calculation of RMI IV and comparing it with the histopathology report, 33 cases out of total 34 benign cases had RMI IV <450 whereas 19 malignant cases had RMI IV score of ≥450 which was confirmed by histopathology in 31 benign cases and 16 malignant cases only giving positive predictive value of 84.2%, negative predictive value of 94%. Sensitivity was found to be 88%, specificity of 91.2% and Diagnostic accuracy of 90.38%. The RMI IV showed the highest AUCS of 0.936 followed by CA 125 of 0.783 AUC and Size of Tumor demonstrated AUCS of 0.662 in the present study. IOTA had better diagnostic performance than RMI IV (chi squared test 36.45 vs 32.53).
Conclusion: Diagnostic performance of IOTA SR is relatively better for prediction of adnexal mass in comparison to RMI IV.
Keywords: Adnexal Mass, IOTA Simple Rules, Ovarian Tumor, Risk of Malignancy Index IV
There are no comments on this title.