Modulation of chondrogenesis by DG11 (Genkwadaphnin) in clonal mouse embryonic ATDC5 cells. (Record no. 704)
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| 000 -LEADER | |
|---|---|
| fixed length control field | 01799 a2200265 4500 |
| 003 - CONTROL NUMBER IDENTIFIER | |
| control field | OSt |
| 005 - DATE AND TIME OF LATEST TRANSACTION | |
| control field | 20230918115749.0 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION | |
| fixed length control field | 191115b ||||| |||| 00| 0 eng d |
| 040 ## - CATALOGING SOURCE | |
| Description conventions | NLM |
| 060 ## - NATIONAL LIBRARY OF MEDICINE CALL NUMBER | |
| Classification number | THS-00233 |
| 100 ## - MAIN ENTRY--PERSONAL NAME | |
| Personal name | Nepal, Manoj. |
| 9 (RLIN) | 1757 |
| 245 ## - TITLE STATEMENT | |
| Title | Modulation of chondrogenesis by DG11 (Genkwadaphnin) in clonal mouse embryonic ATDC5 cells. |
| 260 ## - PUBLICATION, DISTRIBUTION, ETC. | |
| Date of publication, distribution, etc. | c2010. |
| 300 ## - PHYSICAL DESCRIPTION | |
| Extent | ii, 38p. : |
| 500 ## - GENERAL NOTE | |
| General note | Thesis Report. |
| 520 ## - SUMMARY, ETC. | |
| Summary, etc. | ABSTRACT: Endochondral bone formation occurs when mesenchymall cells condense to differentiate into chondrocytes- the primary cell types of cartilage. To identify novel factors that are involved in the control of chondrogensis, we investigated the role of DG 11 to induce chondrogenic diffeerentitation of ATDC5 cells. Accumulation of fcartilage nodules due to chondrocytes differentiation and expression of different chondrocyte- specific gene markers such as type 11 collagen, type X collagen, aggrecan, Sox9, Runx2 and Osterix was observed upon treatment of ATDC5 cells with DG11 in conecentration and time dependent manners. Furthermore, phosphorylation of ERK and JNK but not that of p38 MAP kinase reveals stimulatory effect of DG11 for chondrogenic differentiation. Conversely, induction of chondrogenesis was significantly suppressed by treating ATDC5 cells with PD98059 and SP 600125, potent inhibitors of ERK and JNK MAP kinase, respectively. From the above findings, we assumed the possible therapeutic effect of DG11 against various growth disorders such as dwarfism. |
| 546 ## - LANGUAGE NOTE | |
| Language note | Eng. |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Modulation. |
| 9 (RLIN) | 2814 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Chondrogenesis. |
| 9 (RLIN) | 2815 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | DG11 . |
| 9 (RLIN) | 2816 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | Clonal mouse. |
| 9 (RLIN) | 2817 |
| 650 ## - SUBJECT ADDED ENTRY--TOPICAL TERM | |
| Topical term or geographic name entry element | ATDC5 cells. |
| 9 (RLIN) | 2818 |
| 856 ## - ELECTRONIC LOCATION AND ACCESS | |
| Uniform Resource Identifier | <a href="http://nhrc.gov.np/contact/">http://nhrc.gov.np/contact/</a> |
| Link text | Visit NHRC Library |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) | |
| Source of classification or shelving scheme | National Library of Medicine |
| Koha item type | Thesis Report |
| Withdrawn status | Lost status | Source of classification or shelving scheme | Damaged status | Not for loan | Home library | Current library | Shelving location | Date acquired | Total Checkouts | Full call number | Barcode | Date last seen | Price effective from | Koha item type |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| National Library of Medicine | Nepal Health Research Council | Nepal Health Research Council | Reference | 07/26/2012 | THS00233/NEP/2010 | THS-00233 | 07/26/2012 | 07/26/2012 | Thesis Report |